Sodium Stearyl Fumarate

Introduction

Sodium Stearyl Fumarate is a tablet lubricant created particularly for formulations where alternative lubricants cause formulation and/or manufacturing issues. It has the following benefits over the commonly used lubricant magnesium stearate:

There is no negative impact on dissolution.
Over-lubrication resistance
Improved look of effervescent solutions
API compatibility is relatively higher.

Azathioprin, Cefaclor, Cilazapril, Clopidogrelacetate, Diclofenac, Fosinopril, Ibuprofen, Ketorolac, Levofloxacin, Nifedipine, Omeprazole, Ramipril, and Trandolapril are some of the APIs that have been found to have incompatibility issues with magnesium stearate.

Sodium Stearyl Fumarate helps create new products and is especially well suited for high-speed direct compression of tablets.

Benefits of Sodium Stearyl Fumarate

Improved drug stability.
Faster dissolution rates.
Shorter disintegration times.
Harder tablets.
Less over blending.
More rapid formulation development and scale-up.
Enhanced lubrication efficiency.
It acts as a boundary lubricant.
Less sensitivity to blending time.
Superior hardness characteristics in comparison to tablets produced with magnesium stearate.
Excellent batch-to-batch consistency in comparison to magnesium stearate.

Applications

Wet granulation.
Dry granulation.
Direct compression.
Continuous manufacturing.